Cognitive neuroscience of aging

The research produced by YU-CARE members and associates along the theme of the cognitive neuroscience of aging are impactful at the individual, organizational, and societal levels. Research spans from topics including:

  • Attention;
  • Motor coordination;
  • Executive functioning
    • Bilingualism and aging;
  • Learning;
  • Memory;
  • Perception; and
  • Cognitive therapies and treatments.

Please click the hyperlink (content italicized and underlined in red) at each citation to find each article or abstract.

For a downloadable version of this webpage, please click here.

For a downloadable version of the entire YU-CARE Research Compendium, please click here.

Attention

  1. Spreng, R., Stevens, W., Viviano, J. D., & Schacter, D. L. (2016). Attenuated anticorrelation between the default and dorsal attention networks with aging: evidence from task and rest. Neurobiology of Aging, 45, 149-160.
  2. Kim, T. H., Pascual-Leone, J., Johnson, J., & Tamim, H. (2016). The mental-attrition Tai Chi effect with older adults. BMC Psychology, 4(29).
  3. McLaughlin, P.M., Anderson, N.D., Rich, J.B., Chertkow, H., & Murtha, S.J.E. (2013). Visual selective attention in amnestic mild cognitive impairment. Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 69(6), 881–891.
  4. McLaughlin Paula M., Anderson, Nicole D. Rich, Jill, Chertkow, Howard, Murtha, Susan J. E. (2014) Visual Selective Attention in Amnestic Mild Cognitive Impairment. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 69 (6), 881-891.
  5. Levinoff, E. J., Li, K. Z. H., Murtha, S., & Chertkow, H. (2004). Selective Attention Impairments in Alzheimer's Disease: Evidence for Dissociable Components. Neuropsychology, 18(3), 580-588.

Motor coordination

  1. de Boer C, Eclin H, V, Rogojin A, Baltaretu B, R, Sergio L, E: Thinking-While-Moving Exercises May Improve Cognition in Elderly with Mild Cognitive Deficits: A Proof-of-Principle Study. Dement Geriatr Cogn Disord Extra 2018;:248-258.
  2. Hawkins KM, Sergio LE (2016) Changes in resting-state functional connectivity associated with cognitive-motor impairment in older adults at increased Alzheimer’s disease risk. Alz. Dis.; Jun 18;53(3):1161-72.
  3. Hawkins, K. M., Goyal, A., & Sergio, L. E. (2015). Diffusion tensor imaging correlates of cognitive-motor decline in normal aging and increased Alzheimer's disease risk. Journal of Alzheimer's Disease, 44(3), 867-878.
  4. Schorer, J. & Baker, J. (2009). Aging and perceptual-motor expertise in handball goalkeepers. Experimental Aging Research, 35, 1-19.
  5. Horton, S., Baker, J., & Schorer, J. (2008). Expertise and aging: Maintaining skills throughout the lifespan. European Review of Aging and Physical Activity, 5, 89-96.

Executive functioning

  1. Adnan, A., Chen, A. J. W., Novakovic-Agopian, T., D’Esposito, M., & Turner, G. R. (2017). Brain Changes Following Executive Control Training in Older Adults. Neurorehabilitation and Neural Repair, 31(10–11), 910–922.
  2. Hunt, A., Turner, G.R., Polatajko, H., Bottari, C., Dawson, D. (2013) Executive function, self-regulation and attribution in acquired brain injury:  a scoping review. Neuropsychological Rehabilitation.
  3. Spreng, R.N. & Turner, G.R. (2013). Structural covariance of the default network in healthy and pathological aging. Journal of Neuroscience, 33(38). 15226-15234.
  4. Spreng, R.N., Sepulcre, J., Turner, G.R., Stevens, W.D., & Schacter, D.L. (2013). Intrinsic architecture underlying the relations among the default, dorsal attention, and frontoparietal control networks of the human brain. Journal of Cognitive Neuroscience. 25, 74-86.
  5. Turner, G.R. & Spreng, R.N. (2012). Executive control and neurocognitive aging: Dissociable patterns of brain activity for working memory and inhibition. Neurobiology of Aging. 33, 826.e1–826.e13.
  6. Noakovic-Agopian, T., Chen, A.J.W., Rome, S. Rossi, A., Abrams, G., D’Esposito, M., Turner, G.R. et al., (2012). Assessment of Sub-components of Executive Functioning in Ecologically Valid Settings: The Goal Processing Scale. Journal of Head Trauma Rehabilitation.
  7. DiGirolamo, G. J., Kramer, A. F., Barad, V., Cepeda, N. J., Weissman, D. H., Milham, M. P., Wszalek, T. M., Cohen, N. J., Banich, M. T., Webb, A., Belopolsky, A. V., & McAuley, E. (2001). General and task-specific frontal lobe recruitment in older adults during executive processes: An fMRI investigation of task switching. Neuroreport, 12, 2065-2071.

Bilingualism and aging

  1. Bialystok, E., Abutalebi, J., Bak, T. H., Burke, D. M., & Kroll, J. F. (2016). Aging in two languages: Implications for public health. Ageing Research Reviews, 27, 56-60.
  2. Grady, C. L., Luk, G., Craik, F. I., & Bialystok, E. (2015). Brain network activity in monolingual and bilingual older adults. Neuropsychologia, 66, 170-181.
  3. Friesen, D. C., Luo, L., Luk, G., & Bialystok, E. (2015). Proficiency and control in verbal fluency performance across the lifespan for monolinguals and bilinguals. Language, Cognition and Neuroscience, 30(3), 238-250.
  4. Olsen, R. K., Pangelinan, M. M., Bogulski, C., Chakravarty, M. M., Luk, G., Grady, C. L., & Bialystok, E. (2015). The effect of lifelong bilingualism on regional grey and white matter volume. Brain Research, 1612, 128-139.
  5. Clare, L., Whitaker, C. J., Craik, F. I., Bialystok, E., Martyr, A., Martin-Forbes, P. A., ... Hindle, J. V. (2014). Bilingualism, executive control, and age at diagnosis among people with early-stage Alzheimer’s disease in Wales. Journal of Neuropsychology, 10(2), 163-185.
  6. Morris Freedman, Suvarna Alladi, Howard Chertkow, et al., “Delaying Onset of Dementia: Are Two Languages Enough?,” Behavioural Neurology, vol. 2014, Article ID 808137, 8 pages, 2014. (Bialystok, E.)
  7. Bialystok, E., Craik, F. I. M., Binns, M. A., Ossher, L., & Freedman, M. (2014). Effects of bilingualism on the age of onset and progression of MCI and AD: Evidence from executive function tests. Neuropsychology, 28(2), 290-304.
  8. Bialystok, E., Poarch, G., Luo, L., & Craik, F. I. M. (2014). Effects of bilingualism and aging on executive function and working memory. Psychology and Aging, 29(3), 696-705.
  9. Schweizer, T. A., Craik, F. I., & Bialystok, E. (2013). Bilingualism, not immigration status, is associated with maintained cognitive level in Alzheimer’s disease. Cortex, 49(5), 1442-1443.
  10. Schweizer, T. A., Ware, J., Fischer, C. E., Craik, F. I., & Bialystok, E. (2012). Bilingualism as a contributor to cognitive reserve: Evidence from brain atrophy in Alzheimer’s disease. Cortex, 48(8), 991-996.
  11. Bialystok, E., Craik, F., & Luk, G. (2008). Cognitive control and lexical access in younger and older bilinguals. Journal of Experimental Psychology, 34(4), 859-873.
  12. Bialystok, E., Craik, F. I., & Freedman, M. (2007). Bilingualism as a protection against the onset of symptoms of dementia. Neuropsychologia, 45(2), 459-464.
  13. Fernandes, M. A., Craik, F., Bialystok, E., & Kreuger, S. (2007). Effects of bilingualism, aging, and semantic relatedness on memory under divided attention. Canadian Journal of Experimental Psychology/Revue canadienne de psychologie expérimentale, 61(2), 128-141.

Learning

  1. Ryan, J. D., D'Angelo, M. C., Kamino, D., Ostreicher, M., Moses, S. N., & Rosenbaum, R. S. (2016). Relational learning and transitive expression in aging and amnesia. Hippocampus, 26(2), 170–184.
  2. Ostreicher, M.L., Moses, S.N., Rosenbaum, R.S., & Ryan, J.D. (2010). Prior experience supports new learning of relations in aging. Journal of Gerontology: Psychological Sciences, 65B(1), 32–41
  3. Lubinsky, T., Rich, J., & Anderson, N. (2009). Errorless learning and elaborative self-generation in healthy older adults and individuals with amnestic mild cognitive impairment: Mnemonic benefits and mechanisms. Journal of the International Neuropsychological Society, 15(5), 704-716.

Memory

  1. Hudes, R., Rich, J. B., Troyer, A. K., Yusupov, I., & Vandermorris, S. (2019). The impact of memory-strategy training interventions on participant-reported outcomes in healthy older adults: A systematic review and meta-analysis. Psychology and Aging, 34(4), 587-597.
  2. Curtis, A. F., Park, N. W., Turner, G. R., & Murtha, S. J. E. Improving spatial working memory in younger and older adults: Effects of crossmodal cues.  2016 Cognitive Aging Conference, Atlanta, Georgia.
  3. Komal T Shaikh, Erica L Tatham, Preeyam K Parikh, Graham A McCreath, Jill B Rich, Angela K Troyer, Development and Psychometric Validation of a Questionnaire Assessing the Impact of Memory Changes in Older Adults, The Gerontologist.
  4. Bercovitz, K. E., Bell, M. C., Simone, P. M., & Wiseheart, M. (2017). The spacing effect in older and younger adults: Does context matter? Aging, Neuropsychology, and Cognition, 24, 703-716.
  5. Simone, P. M., Bell, M., & Cepeda, N. J. (2013). Diminished but not forgotten: Effects of aging on magnitude of spacing effect benefits. The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 68, 674-680.
  6. Rosenbaum, R., Winocur, G., Binns, M. A., & Moscovitch, M. (2012). Remote spatial memory in aging: all is not lost. Frontiers in Aging Neuroscience.
  7. Crete-Nishihata, M., Baecker, R.M., Massimi, M., Ptak, D., Campigotto, R., Kaufman, L.D., Brickman, A.M., Turner, G.R., Steinerman, J., and Black, S.E. (2012). Reconstructing the Past: Personal Memory Technologies Are Not Just Personal and Not Just for Memory. Human-Computer Interaction. 27(1-2). 1-32.
  8. Winocur, G., Moscovitch, M., Rosenbaum, R. S., & Sekeres, M. (2010). A study of remote spatial memory in aged rats. Neurobiology of Aging, 31, 143-150.
  9. Rosenbaum, R. S., Furey, M. L., Horwitz, B., & Grady, C. L. (2010). Altered connectivity among emotion-related brain regions during short-term memory in Alzheimer's disease. Neurobiology of aging, 31(5), 780–786.
  10. Karantzoulis, S., Troyer, A., & Rich, J. (2009). Prospective memory in amnestic mild cognitive impairment. Journal of the International Neuropsychological Society, 15(3), 407-415.
  11. Levine, B., Svoboda, E.M., Turner, G.R., Mandic, M., & Mackey, A. (2009). Behavioral and functional neuroanatomical correlates of autobiographical memory in isolated retrograde amnesic patient M.L. Neuropsychologia, 47(11). Pages 2188-2196
  12. Stevens, W., Hasher, L., Chew, K. S., & Grady, C. L. (2008). A neural mechanism underlying memory failure in older adults. The Journal of Neuroscience, 28(48), 12820-12824.
  13. Roncadin, C., Pascual-Leone, J., Rich, J., & Dennis, M. (2007). Developmental relations between working memory and inhibitory control. Journal of the International Neuropsychological Society, 13(1), 59-67.
  14. Phillips, N. A., Chertkow, H., Leblanc, M. M., Pim, H., & Murtha, S. (2004). Functional and anatomical memory indices in patients with or at risk for Alzheimer's disease. Journal of the International Neuropsychological Society, 10, 200-210.
  15. Troyer, A. K., & Rich, J. B. (2002). Psychometric properties of a new metamemory questionnaire for older adults. Journal of Gerontology: Psychological Sciences, 57B(1), 19-27.
  16. Fung, T. D., Chertkow, H., Murtha, S., Whatmough, C., Péloquin, L., Whitehead, V., & Templeman, F. D. (2001). The spectrum of category effects in object and action knowledge in dementia of the Alzheimer's type. Neuropsychology, 15(3), 371-379.

Perception

  1. Massie, A. S., & Meisner, B. A. (2019). Perceptions of aging and experiences of ageism as constraining factors of moderate to vigorous leisure-time physical activity in later life. Society & Leisure, 42(1), 24-42.
  2. Harris LR, Jenkin M, Dyde RT, Jenkin H (2011) “Enhancing visual cues to orientation: suggestions for space travellers and the elderly”. Progress in Brain Research 191: 133-142
  3. Wilson, H. R., Mei, M., Habak, C., & Wilkinson, F. (2011). Visual bandwidths for face orientation increase during healthy aging. Vision Research, 51, 160-164.
  4. McLaughlin, P.M., Murtha, S.J.E. (2010). The effects of age and exogenous support on visual search performance. Experimental Aging Research, 26 (3), p325-345.
  5. Habak, C., Wilkinson, F., & Wilson, H. R. (2008). Aging disrupts the neural transformations that link facial identity across views. Vision Research, 48(1), 9-15.
  6. Habak, C., Wilkinson, F., & Wilson, H. R. (2009). Preservation of shape discrimination in aging. Journal of Vision, 9(18).
  7. Tippett W, J, Krajewski A, Sergio L, E: Visuomotor Integration Is Compromised in Alzheimer’s Disease Patients Reaching for Remembered Targets. Eur Neurol 2007;58:1-11.
  8. Tippett, W. J., & Sergio, L. E. (2006). Visuomotor integration is impaired in early stage Alzheimer's disease. Brain Research, 1102, 92-102.
  9. Rivest J, Kim J, S, Intriligator J, Sharpe J, A: Effect of Aging on Visual Shape Distortion. Gerontology 2004;50:142-151.

Cognitive therapies and treatments

  1. Patel, R., Spreng, R.N. & Turner, G.R. (2013). Functional brain changes following cognitive and motor skills training: A quantitative meta-analysis. Neurorehabilitation and Neural Repair, 27, 187–199.
  2. Saumier, D., Murtha, S., Bergman, H., Phillips, N., Whitehead, V., & Chertkow, H. (2007). Cognitive predictors of donepezil therapy response in Alzheimer disease. Dementia and Geriatric Cognitive Disorders, 24, 28-35.
  3. Mohr, E., Nair, V., Sampson, M., Murtha, S., Belanger, G., Pappas, B., & Mendia, T. (1997). Treatment of Alzheimer's disease with sabeluzole: Functional and structural correlates. Clinical Neuropharmacology, 20(4), 338-345.
  4. Rapp, M. S., Flint, A. J., Herrmann, N., & Proulx, G.-B. (1992). Behavioural disturbances in the demented elderly: Phenomenology, pharmacotherapy and behavioural management*. The Canadian Journal of Psychiatry, 37(9), 651–657.